TY - JOUR
T1 - Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases
AU - Lee, Kyungwon
AU - Kim, Chang Ki
AU - Hong, Seong Geun
AU - Choi, Jonghyeon
AU - Song, Sungwook
AU - Koh, Eunmi
AU - Yong, Dongeun
AU - Jeong, Seok Hoon
AU - Yum, Jong Hwa
AU - Docquier, Jean Denis
AU - Rossolini, Gian Maria
AU - Chong, Yunsop
PY - 2010/9
Y1 - 2010/9
N2 - Acquired metallo-β-lactamase (MBL) production is an important mechanism of carbapenem resistance. To our knowledge, carriage of two different MBLs has not been described previously in Acinetobacter spp. We present the characteristics of five Acinetobacter isolates carrying two different MBL genes. The species of all five Acinetobacter isolates with two different MBL genes were Acinetobacter genomospecies 10, and blaIMP-1, blaVIM-2 and blaSIM-1 may coexist in this species. Minimum inhibitory concentrations (MICs) of imipenem for all five isolates with two different MBLs were ≥32μg/mL, whilst those for two segregants that lost both MBLs were 0.5μg/mL. The presence of MBL gene-carrying integrons with identical structures suggested the easily transferable nature of the elements, whilst instability of the MBL genes indicated potentially erroneous phenotypic and genetic characterisation.
AB - Acquired metallo-β-lactamase (MBL) production is an important mechanism of carbapenem resistance. To our knowledge, carriage of two different MBLs has not been described previously in Acinetobacter spp. We present the characteristics of five Acinetobacter isolates carrying two different MBL genes. The species of all five Acinetobacter isolates with two different MBL genes were Acinetobacter genomospecies 10, and blaIMP-1, blaVIM-2 and blaSIM-1 may coexist in this species. Minimum inhibitory concentrations (MICs) of imipenem for all five isolates with two different MBLs were ≥32μg/mL, whilst those for two segregants that lost both MBLs were 0.5μg/mL. The presence of MBL gene-carrying integrons with identical structures suggested the easily transferable nature of the elements, whilst instability of the MBL genes indicated potentially erroneous phenotypic and genetic characterisation.
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U2 - 10.1016/j.ijantimicag.2010.05.018
DO - 10.1016/j.ijantimicag.2010.05.018
M3 - Article
C2 - 20599361
AN - SCOPUS:77954956595
SN - 0924-8579
VL - 36
SP - 259
EP - 263
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 3
ER -
