Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins

Sun Mi Park, Shimin Hu, Tae H. Lee, Xiaolu Yang

Research output: Chapter in Book/Report/Conference proceedingChapter


Inhibitor of apoptosis (IAP) proteins are a family of evolutionarily conserved proteins that regulate apoptosis as well as other cellular processes. The functions of many IAPs are defined by their RING domains, which possess E3 ubiquitin ligase activity and promote proteasomal degradation of an increasing number of target proteins. In this chapter, we describe the methods used in our laboratories to study the IAP's E3 activity.

Original languageEnglish
Title of host publicationProgrammed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B
EditorsRoya Khosravi-Far, Zahra Zakeri, Richard Lockshin, Mauro Piacentini
Number of pages11
Publication statusPublished - 2008

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879

Bibliographical note

Funding Information:
This work was supported by NIH grants CA88868 and CA108872 and a Leukemia & Lymphoma Society Scholar award to X. Y., and the Korea Research Foundation Grant (KRF‐2006‐005‐J04502) and Brain Korea 21 project to T.H.L. The authors are grateful for critical reading of the manuscript by the members of the Yang laboratory.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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