Chaperna: linking the ancient RNA and protein worlds

Ahyun Son, Scott Horowitz, Baik L. Seong

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with proteins of biological relevance. The ribozyme-resident protein folding activity, even before the advent of protein-based molecular chaperone, must have expedited the transition of the RNA world into the present protein theatre.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalRNA Biology
Issue number1
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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