TY - JOUR
T1 - Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
AU - Lee, Su Hyeon
AU - Kang, Se Mi
AU - Choi, Man Ho
AU - Lee, Jeongae
AU - Park, Mi Jung
AU - Kim, Shin Hye
AU - Lee, Won Yong
AU - Hong, Jongki
AU - Chung, Bong Chul
PY - 2014/4
Y1 - 2014/4
N2 - Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P< 0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP.
AB - Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P< 0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP.
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U2 - 10.1016/j.reprotox.2013.03.008
DO - 10.1016/j.reprotox.2013.03.008
M3 - Article
C2 - 23557689
AN - SCOPUS:84899421319
SN - 0890-6238
VL - 44
SP - 1
EP - 6
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -