Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients

Seung Kyu Park, Sunghee Hong, Seok Yong Eum, In Hee Lee, Donk Ok Shin, Jang Eun Cho, Sungae Cho, Sang Nae Cho

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6 Citations (Scopus)


The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
Issue number4
Publication statusPublished - 2011 Jul

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Health 21 R & D Project, Ministry of Health and Welfare , Republic of Korea ( A010381 ), and by a grant from the Brain Korea Project for Medical Sciences at Yonsei University.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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