Changes in Automated Mammographic Breast Density Can Predict Pathological Response After Neoadjuvant Chemotherapy in Breast Cancer

Jee Hyun Ahn; Jieon Go; Suk Jun Lee; Jee Ye Kim; Hyung Seok Park; Seung Il Kim; Byeong Woo Park; Vivian Youngjean Park; Jung Hyun Yoon; Min Jung Kim; Seho Park

doi:10.3348/kjr.2022.0629

Changes in Automated Mammographic Breast Density Can Predict Pathological Response After Neoadjuvant Chemotherapy in Breast Cancer

Jee Hyun Ahn, Jieon Go, Suk Jun Lee, Jee Ye Kim, Hyung Seok Park, Seung Il Kim, Byeong Woo Park, Vivian Youngjean Park, Jung Hyun Yoon, Min Jung Kim, Seho Park

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT − pre-NCT)/pre-NCT Vbd x 100 (%). The stable, decreased, and increased groups were defined as-20% ≤ ΔVbd% ≤ 20%, ΔVbd% <-20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195–0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.

Original language	English
Pages (from-to)	384-394
Number of pages	11
Journal	Korean journal of radiology
Volume	24
Issue number	5
DOIs	https://doi.org/10.3348/kjr.2022.0629
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Korean Society of Radiology.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3348/kjr.2022.0629

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@article{497012d574f94b588384853c1a8c417c,

title = "Changes in Automated Mammographic Breast Density Can Predict Pathological Response After Neoadjuvant Chemotherapy in Breast Cancer",

abstract = "Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT − pre-NCT)/pre-NCT Vbd x 100 (%). The stable, decreased, and increased groups were defined as-20% ≤ ΔVbd% ≤ 20%, ΔVbd% <-20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195–0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.",

keywords = "Biomarkers, Breast density, Breast neoplasm, Mammography, Neoadjuvant therapy, Predictive value of tests",

author = "Ahn, {Jee Hyun} and Jieon Go and Lee, {Suk Jun} and Kim, {Jee Ye} and Park, {Hyung Seok} and Kim, {Seung Il} and Park, {Byeong Woo} and Park, {Vivian Youngjean} and Yoon, {Jung Hyun} and Kim, {Min Jung} and Seho Park",

note = "Publisher Copyright: {\textcopyright} 2023 The Korean Society of Radiology.",

year = "2023",

doi = "10.3348/kjr.2022.0629",

language = "English",

volume = "24",

pages = "384--394",

journal = "Korean journal of radiology",

issn = "1229-6929",

publisher = "Korean Radiological Society",

number = "5",

}

TY - JOUR

T1 - Changes in Automated Mammographic Breast Density Can Predict Pathological Response After Neoadjuvant Chemotherapy in Breast Cancer

AU - Ahn, Jee Hyun

AU - Go, Jieon

AU - Lee, Suk Jun

AU - Kim, Jee Ye

AU - Park, Hyung Seok

AU - Kim, Seung Il

AU - Park, Byeong Woo

AU - Park, Vivian Youngjean

AU - Yoon, Jung Hyun

AU - Kim, Min Jung

AU - Park, Seho

PY - 2023

Y1 - 2023

N2 - Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT − pre-NCT)/pre-NCT Vbd x 100 (%). The stable, decreased, and increased groups were defined as-20% ≤ ΔVbd% ≤ 20%, ΔVbd% <-20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195–0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.

AB - Objective: Mammographic density is an independent risk factor for breast cancer that can change after neoadjuvant chemotherapy (NCT). This study aimed to evaluate percent changes in volumetric breast density (ΔVbd%) before and after NCT measured automatically and determine its value as a predictive marker of pathological response to NCT. Materials and Methods: A total of 357 patients with breast cancer treated between January 2014 and December 2016 were included. An automated volumetric breast density (Vbd) measurement method was used to calculate Vbd on mammography before and after NCT. Patients were divided into three groups according to ΔVbd%, calculated as follows: Vbd (post-NCT − pre-NCT)/pre-NCT Vbd x 100 (%). The stable, decreased, and increased groups were defined as-20% ≤ ΔVbd% ≤ 20%, ΔVbd% <-20%, and ΔVbd% > 20%, respectively. Pathological complete response (pCR) was considered to be achieved after NCT if there was no evidence of invasive carcinoma in the breast or metastatic tumors in the axillary and regional lymph nodes on surgical pathology. The association between ΔVbd% grouping and pCR was analyzed using univariable and multivariable logistic regression analyses. Results: The interval between the pre-NCT and post-NCT mammograms ranged from 79 to 250 days (median, 170 days). In the multivariable analysis, ΔVbd% grouping (odds ratio for pCR of 0.420 [95% confidence interval, 0.195–0.905; P = 0.027] for the decreased group compared with the stable group), N stage at diagnosis, histologic grade, and breast cancer subtype were significantly associated with pCR. This tendency was more evident in the luminal B-like and triple-negative subtypes. Conclusion: ΔVbd% was associated with pCR in breast cancer after NCT, with the decreased group showing a lower rate of pCR than the stable group. Automated measurement of ΔVbd% may help predict the NCT response and prognosis in breast cancer.

KW - Biomarkers

KW - Breast density

KW - Breast neoplasm

KW - Mammography

KW - Neoadjuvant therapy

KW - Predictive value of tests

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DO - 10.3348/kjr.2022.0629

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C2 - 37133209

AN - SCOPUS:85157965638

SN - 1229-6929

VL - 24

SP - 384

EP - 394

JO - Korean journal of radiology

JF - Korean journal of radiology

IS - 5

ER -

Changes in Automated Mammographic Breast Density Can Predict Pathological Response After Neoadjuvant Chemotherapy in Breast Cancer

Abstract

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