Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy

Cheol Whan Lee, Jung Hee Lee, Jae Joong Kim, Seong Wook Park, Myeong Ki Hong, Sang Tae Kim, Tae Hwan Lim, Seung Jung Park

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


OBJECTIVES: Using proton magnetic resonance spectroscopy, we investigated cerebral metabolism and its determinants in congestive heart failure (CHF), and the effects of cardiac transplantation on these measurements. BACKGROUND: Few data are available about cerebral metabolism in CHF. METHODS: Fifty patients with CHF (ejection fraction ≤35%) and 20 healthy volunteers were included for this study. Of the patients, 10 patients underwent heart transplantation. All subjects performed symptom-limited bicycle exercise test. Proton magnetic resonance spectroscopy (1H MRS) was obtained from localized regions (8 to 10 ml) of occipital gray matter (OGM) and parietal white matter (PWM). Absolute levels of the metabolites (N- acetylaspartate, creatine, choline, myo-inositol) were calculated. RESULTS: In PWM only creatine level was significantly lower in CHF than in control subjects, but in OGM all four metabolite levels were decreased in CHF. The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0.56, p < 0.05), and with peak oxygen consumption and serum sodium concentration in OGM (r = 0.58, p < 0.05). Cerebral metabolic abnormalities were improved after successful cardiac transplantation. CONCLUSIONS: This study shows that cerebral metabolism is abnormally deranged in advanced CHF and it may serve as a potential marker of the disease severity.

Original languageEnglish
Pages (from-to)1196-1202
Number of pages7
JournalJournal of the American College of Cardiology
Issue number5
Publication statusPublished - 1999 Apr

Bibliographical note

Funding Information:
This study was supported in part by The Korea Science and Engineering Foundation (KOSEF) during 1996–1998 (grant #961-0706-049-2) and by the Asan Institute for Life Science (grant #98-217).

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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