TY - JOUR
T1 - CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations
AU - Seok, Yoonmi
AU - Kim, Juwon
AU - Choi, Jong Rak
AU - Kim, Yu Ri
AU - Park, Seo Jin
AU - Kim, Sue Jung
AU - Song, Jaewoo
AU - Lee, Kyung A.
PY - 2012/1
Y1 - 2012/1
N2 - The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
AB - The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
UR - http://www.scopus.com/inward/record.url?scp=84859569470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859569470&partnerID=8YFLogxK
U2 - 10.3343/alm.2012.32.1.95
DO - 10.3343/alm.2012.32.1.95
M3 - Article
C2 - 22259787
AN - SCOPUS:84859569470
SN - 2234-3806
VL - 32
SP - 95
EP - 98
JO - Annals of laboratory medicine
JF - Annals of laboratory medicine
IS - 1
ER -