CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations

Yoonmi Seok, Juwon Kim, Jong Rak Choi, Yu Ri Kim, Seo Jin Park, Sue Jung Kim, Jaewoo Song, Kyung A. Lee

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalAnnals of laboratory medicine
Issue number1
Publication statusPublished - 2012 Jan

All Science Journal Classification (ASJC) codes

  • Biochemistry, medical
  • Clinical Biochemistry


Dive into the research topics of 'CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations'. Together they form a unique fingerprint.

Cite this