Cardiac 123I-MIBG scintigraphy in patients with essential tremor

Phil Hyu Lee; Ji Woo Kim; Oh Young Bang; In Soo Joo; Seok Nam Yoon; Kyoon Huh

doi:10.1002/mds.20908

Cardiac ¹²³I-MIBG scintigraphy in patients with essential tremor

Phil Hyu Lee, Ji Woo Kim, Oh Young Bang, In Soo Joo, Seok Nam Yoon, Kyoon Huh

Department of Neurology

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

In some cases, it is difficult to differentiate essential tremor (ET) from Parkinson's disease (PD), especially in the early stages of the disease. We investigated cardiac sympathetic dysfunction using ¹²³I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 22 patients with ET, in comparison with early PD and tremor-dominant PD (TDPD). The mean ratio of ¹²³I-MIBG uptake in the region of interest in the heart to that in the mediastinum (H/M ratio) was significantly greater in patients with ET (1.99 ± 0.21) than in those with either TDPD (1.28 ± 0.11) or early PD (1.28 ± 0.17; each P < 0.001). The H/M ratio in all patients with ET was greater than two standard deviations above the range of the ratio in the patients with early PD or TDPD.

Original language	English
Pages (from-to)	1235-1238
Number of pages	4
Journal	Movement Disorders
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/mds.20908
Publication status	Published - 2006 Aug

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1002/mds.20908

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abstract = "In some cases, it is difficult to differentiate essential tremor (ET) from Parkinson's disease (PD), especially in the early stages of the disease. We investigated cardiac sympathetic dysfunction using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 22 patients with ET, in comparison with early PD and tremor-dominant PD (TDPD). The mean ratio of 123I-MIBG uptake in the region of interest in the heart to that in the mediastinum (H/M ratio) was significantly greater in patients with ET (1.99 ± 0.21) than in those with either TDPD (1.28 ± 0.11) or early PD (1.28 ± 0.17; each P < 0.001). The H/M ratio in all patients with ET was greater than two standard deviations above the range of the ratio in the patients with early PD or TDPD.",

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AU - Yoon, Seok Nam

AU - Huh, Kyoon

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AB - In some cases, it is difficult to differentiate essential tremor (ET) from Parkinson's disease (PD), especially in the early stages of the disease. We investigated cardiac sympathetic dysfunction using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 22 patients with ET, in comparison with early PD and tremor-dominant PD (TDPD). The mean ratio of 123I-MIBG uptake in the region of interest in the heart to that in the mediastinum (H/M ratio) was significantly greater in patients with ET (1.99 ± 0.21) than in those with either TDPD (1.28 ± 0.11) or early PD (1.28 ± 0.17; each P < 0.001). The H/M ratio in all patients with ET was greater than two standard deviations above the range of the ratio in the patients with early PD or TDPD.

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Cardiac ¹²³I-MIBG scintigraphy in patients with essential tremor

Abstract

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