Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

Wan Seob Cho; Beom Seok Han; Ki Taek Nam; Kidae Park; Mina Choi; Seung Hee Kim; Jayoung Jeong; Dong Deuk Jang

doi:10.1016/j.fct.2008.07.003

Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

Wan Seob Cho, Beom Seok Han, Ki Taek Nam, Kidae Park, Mina Choi, Seung Hee Kim, Jayoung Jeong, Dong Deuk Jang

BioMedical Science Institute

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

Original language	English
Pages (from-to)	3172-3177
Number of pages	6
Journal	Food and Chemical Toxicology
Volume	46
Issue number	9
DOIs	https://doi.org/10.1016/j.fct.2008.07.003
Publication status	Published - 2008 Sept

Bibliographical note

Funding Information:
This research was supported by a Grant (05121KFDA455) from Korea Food and Drug Administration from 2002 to 2005.

All Science Journal Classification (ASJC) codes

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2008.07.003

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title = "Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats",

abstract = "3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.",

author = "Cho, {Wan Seob} and Han, {Beom Seok} and Nam, {Ki Taek} and Kidae Park and Mina Choi and Kim, {Seung Hee} and Jayoung Jeong and Jang, {Dong Deuk}",

note = "Funding Information: This research was supported by a Grant (05121KFDA455) from Korea Food and Drug Administration from 2002 to 2005.",

year = "2008",

month = sep,

doi = "10.1016/j.fct.2008.07.003",

language = "English",

volume = "46",

pages = "3172--3177",

journal = "Food and Chemical Toxicology",

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publisher = "Elsevier Limited",

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TY - JOUR

T1 - Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

AU - Cho, Wan Seob

AU - Han, Beom Seok

AU - Nam, Ki Taek

AU - Park, Kidae

AU - Choi, Mina

AU - Kim, Seung Hee

AU - Jeong, Jayoung

AU - Jang, Dong Deuk

N1 - Funding Information: This research was supported by a Grant (05121KFDA455) from Korea Food and Drug Administration from 2002 to 2005.

PY - 2008/9

Y1 - 2008/9

N2 - 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

AB - 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.

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JO - Food and Chemical Toxicology

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ER -

Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats

Abstract

Bibliographical note

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UN SDGs

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