Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy

Hyoung Won Baac; Jong G. Ok; Adam Maxwell; Kyu Tae Lee; Yu Chih Chen; A. John Hart; Zhen Xu; Euisik Yoon; L. Jay Guo

doi:10.1038/srep00989

Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy

Hyoung Won Baac, Jong G. Ok, Adam Maxwell, Kyu Tae Lee, Yu Chih Chen, A. John Hart, Zhen Xu, Euisik Yoon, L. Jay Guo

Yonsei Advanced Science Institute

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

Abstract

We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and elastomeric polymer is formed on concave lenses, and used as an efficient optoacoustic source due to the high optical absorption of the CNTs and rapid heat transfer to the polymer upon excitation by pulsed laser irradiation. The CNT-coated lenses can generate unprecedented optoacoustic pressures of >50 MPa in peak positive on a tight focal spot of 75 μm in lateral and 400 μm in axial widths. This pressure amplitude is remarkably high in this frequency regime, producing pronounced shock effects and non-thermal pulsed cavitation at the focal zone. We demonstrate that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells.

Original language	English
Article number	989
Journal	Scientific reports
Volume	2
DOIs	https://doi.org/10.1038/srep00989
Publication status	Published - 2012

Bibliographical note

Funding Information:
The authors would like to acknowledge the support from the National Science grant DMR 1120187, the National Institute of Health, and the University of Michigan. The authors also wish to acknowledge Simone Park for using the high-speed camera. H.W.B. acknowledges the support from the National Institute for International Education through Korean Ministry of Education, Science and Technology.

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1038/srep00989

Cite this

@article{76d0a63e81ba43fb9a1e51c6ababea16,

title = "Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy",

abstract = "We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and elastomeric polymer is formed on concave lenses, and used as an efficient optoacoustic source due to the high optical absorption of the CNTs and rapid heat transfer to the polymer upon excitation by pulsed laser irradiation. The CNT-coated lenses can generate unprecedented optoacoustic pressures of >50 MPa in peak positive on a tight focal spot of 75 μm in lateral and 400 μm in axial widths. This pressure amplitude is remarkably high in this frequency regime, producing pronounced shock effects and non-thermal pulsed cavitation at the focal zone. We demonstrate that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells.",

author = "Baac, {Hyoung Won} and Ok, {Jong G.} and Adam Maxwell and Lee, {Kyu Tae} and Chen, {Yu Chih} and Hart, {A. John} and Zhen Xu and Euisik Yoon and Guo, {L. Jay}",

note = "Funding Information: The authors would like to acknowledge the support from the National Science grant DMR 1120187, the National Institute of Health, and the University of Michigan. The authors also wish to acknowledge Simone Park for using the high-speed camera. H.W.B. acknowledges the support from the National Institute for International Education through Korean Ministry of Education, Science and Technology.",

year = "2012",

doi = "10.1038/srep00989",

language = "English",

volume = "2",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy

AU - Baac, Hyoung Won

AU - Ok, Jong G.

AU - Maxwell, Adam

AU - Lee, Kyu Tae

AU - Chen, Yu Chih

AU - Hart, A. John

AU - Xu, Zhen

AU - Yoon, Euisik

AU - Guo, L. Jay

N1 - Funding Information: The authors would like to acknowledge the support from the National Science grant DMR 1120187, the National Institute of Health, and the University of Michigan. The authors also wish to acknowledge Simone Park for using the high-speed camera. H.W.B. acknowledges the support from the National Institute for International Education through Korean Ministry of Education, Science and Technology.

PY - 2012

Y1 - 2012

N2 - We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and elastomeric polymer is formed on concave lenses, and used as an efficient optoacoustic source due to the high optical absorption of the CNTs and rapid heat transfer to the polymer upon excitation by pulsed laser irradiation. The CNT-coated lenses can generate unprecedented optoacoustic pressures of >50 MPa in peak positive on a tight focal spot of 75 μm in lateral and 400 μm in axial widths. This pressure amplitude is remarkably high in this frequency regime, producing pronounced shock effects and non-thermal pulsed cavitation at the focal zone. We demonstrate that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells.

AB - We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) and elastomeric polymer is formed on concave lenses, and used as an efficient optoacoustic source due to the high optical absorption of the CNTs and rapid heat transfer to the polymer upon excitation by pulsed laser irradiation. The CNT-coated lenses can generate unprecedented optoacoustic pressures of >50 MPa in peak positive on a tight focal spot of 75 μm in lateral and 400 μm in axial widths. This pressure amplitude is remarkably high in this frequency regime, producing pronounced shock effects and non-thermal pulsed cavitation at the focal zone. We demonstrate that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells.

UR - http://www.scopus.com/inward/record.url?scp=84871741875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871741875&partnerID=8YFLogxK

U2 - 10.1038/srep00989

DO - 10.1038/srep00989

M3 - Article

C2 - 23251775

AN - SCOPUS:84871741875

SN - 2045-2322

VL - 2

JO - Scientific reports

JF - Scientific reports

M1 - 989

ER -

Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this