Carbon-ion radiotherapy in osteosarcoma of the mandible: A case report

Tae Wook Ha, Slmaro Park, Min Yeong Youn, Dong Wook Kim, Hyung Jun Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, and forms an asymptotic dose peak (the “Bragg peak”). Compared to protons, carbon with its larger mass decreases beam scattering, resulting in a sharper dose distribution border. We report a 50-year-old male who underwent CIRT without surgical resection on osteosarcoma of the mandible. After CIRT, the patient's pain was gone, and the malignant mass remained stable with accompanying necrosis. Nine months later, however, magnetic resonance imaging demonstrated progression of the left mandibular osteosarcoma with pulmonary metastases. After multidisciplinary discussion, concurrent chemoradiotherapy was conducted. While necrotic bone segments came out of the mandible during subsequent periodic outpatient visits, the tumor itself was stable. Thirty months after his first visit and diagnosis, the patient is waiting for chemotherapy. Although CIRT is superior in treating radioresistant hypoxic disease, CIRT is in its infancy, so care must be taken for its indications and complications.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalJournal of the Korean Association of Oral and Maxillofacial Surgeons
Issue number4
Publication statusPublished - 2021 Aug 31

Bibliographical note

Publisher Copyright:
Copyright © 2021 The Korean Association of Oral and Maxillofacial Surgeons.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery


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