Calcium signalling - An overview

Martin D. Bootman, Tony J. Collins, Claire M. Peppiatt, Larissa S. Prothero, Lauren MacKenzie, Patrick De Smet, Marianne Travers, Stephen C. Tovey, Jeong T. Seo, Michael J. Berridge, Francesca Ciccolini, Peter Lipp

Research output: Contribution to journalArticlepeer-review

400 Citations (Scopus)


Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue), muscle contraction and cell proliferation. The ability of a simple ion such as Ca2+ to play a pivotal role in cell biology results from the facility that cells have to shape Ca2+ signals in the dimensions of space, time and amplitude. To generate the variety of observed Ca2+ signals, different cell types employ components selected from a Ca2+ signalling 'toolkit' which comprizes an array of signalling, homeostatic and sensory mechanisms. By mixing and matching components from the toolkit, cells can obtain Ca2+ signals that suit their physiology.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalSeminars in Cell and Developmental Biology
Issue number1
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology


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