TY - JOUR
T1 - Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes
AU - McGary, Kriston L.
AU - Lee, Insuk
AU - Marcotte, Edward M.
PY - 2007/12/5
Y1 - 2007/12/5
N2 - We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.
AB - We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.
UR - http://www.scopus.com/inward/record.url?scp=40449107017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40449107017&partnerID=8YFLogxK
U2 - 10.1186/gb-2007-8-12-r258
DO - 10.1186/gb-2007-8-12-r258
M3 - Article
C2 - 18053250
AN - SCOPUS:40449107017
SN - 1474-7596
VL - 8
JO - Genome Biology
JF - Genome Biology
IS - 12
M1 - R258
ER -
