Bone regeneration using n-methyl-2-pyrrolidone as an enhancer for recombinant human bone morphogenetic protein-2 in a rabbit sinus augmentation model

Hyun Chang Lim, Daniel S. Thoma, So Ra Yoon, Jae Kook Cha, Jung Seok Lee, Ui Won Jung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed. Bone formation in all groups was predominantly located close to the access window and the lateral walls. Newly formed bone within the total augmented area (NBTA) was greatest in BMP/NMP (1.94±0.69 mm2), followed by BMP (1.50±0.72 mm2) and BCP (1.28±0.52 mm2) (P>0.05). In the center of the augmentation (NBROI-C) and the area close to the sinus membrane (NBROI-M), BMP/NMP produced the largest area of NB (NBROI-C: 0.10±0.11 mm2; NBROI-M: 0.17±0.08 mm2); the corresponding NB values for BCP were 0.05±0.05 mm2 and 0.08±0.09 mm2, respectively (P>0.05 for all comparisons). The effect of NMP on bone regeneration was inconsistent between the specimens. Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.

Original languageEnglish
Article number4153073
JournalBioMed Research International
Volume2017
DOIs
Publication statusPublished - 2017

Bibliographical note

Publisher Copyright:
© 2017 Hyun-Chang Lim et al.

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology

Fingerprint

Dive into the research topics of 'Bone regeneration using n-methyl-2-pyrrolidone as an enhancer for recombinant human bone morphogenetic protein-2 in a rabbit sinus augmentation model'. Together they form a unique fingerprint.

Cite this