Bone formation in calvarial defects of Sprague-Dawley rats by transplantation of calcium phosphate glass

Hyun Ju Moon, Kyoung Nam Kim, Kwang Mahn Kim, Seong Ho Choi, Chong Kwan Kim, Kee Deog Kim, Racquel Z. LeGeros, Yong Keun Lee

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The purpose of this study was to investigate the bone-regenerative effect of calcium phosphate glass in vivo. We prepared amorphous calcium phosphate glass powder having a mean particle size of 400 μm in the system CaO-CaF 2-P2O5-MgO-ZnO. Calvarial critical-sized defects (8 mm) were created in 60 male Sprague-Dawley rats. The animals were divided into an experimental group and control group of 30 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As a control, the defect was left empty. The rats were sacrificed 2, 4, or 8 weeks postsurgery, and the results evaluated using radiodensitometric and histological studies; they were also examined histomorphometrically. When the calcium phosphate glass powders with 400-μm particles were grafted, the defects were nearly completely filled with new-formed bone in a clean healing condition after 8 weeks. It was observed that the prepared calcium phosphate glass enhanced new bone formation in the calvarial defect of Sprague-Dawley rats and could be expected to have potential for use as a hard tissue regeneration material.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Issue number3
Publication statusPublished - 2005 Sept 1

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


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