Blood-brain barrier-on-a-chip for brain disease modeling and drug testing

Baofang Cui, Seung Woo Cho

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The blood-brain barrier (BBB) is an interface between cerebral blood and the brain parenchyma. As a gate keeper, BBB regulates passage of nutrients and exogeneous compounds. Owing to this highly selective barrier, many drugs targeting brain diseases are not likely to pass through the BBB. Thus, a large amount of time and cost have been paid for the development of BBB targeted therapeutics. However, many drugs validated in in vitro models and animal models have failed in clinical trials primarily due to the lack of an appropriate BBB model. Human BBB has a unique cellular architecture. Different physiologies between human and animal BBB hinder the prediction of drug responses. Therefore, a more physiologically relevant alternative BBB model needs to be developed. In this review, we summarize major features of human BBB and current BBB models and describe organ-on-chip models for BBB modeling and their applications in neurological complications.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalBMB reports
Issue number5
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This work was supported by Samsung Research Funding & Incubation Center of Samsung Electronics (Project Number SRFC-TC2003-03).

Publisher Copyright:
© 2022. by the The Korean Society for Biochemistry and Molecular Biology

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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