Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Jiho Shin, Ying Yan, Wubin Bai, Yeguang Xue, Paul Gamble, Limei Tian, Irawati Kandela, Chad R. Haney, William Spees, Yechan Lee, Minseok Choi, Jonathan Ko, Hangyu Ryu, Jan Kai Chang, Maryam Pezhouh, Seung Kyun Kang, Sang Min Won, Ki Jun Yu, Jianing Zhao, Yoon Kyeung LeeMatthew R. MacEwan, Sheng Kwei Song, Yonggang Huang, Wilson Z. Ray, John A. Rogers

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)


Pressures in the intracranial, intraocular and intravascular spaces are clinically useful for the diagnosis and management of traumatic brain injury, glaucoma and hypertension, respectively. Conventional devices for measuring these pressures require surgical extraction after a relevant operational time frame. Bioresorbable sensors, by contrast, eliminate this requirement, thereby minimizing the risk of infection, decreasing the costs of care and reducing distress and pain for the patient. However, the operational lifetimes of bioresorbable pressure sensors available at present fall short of many clinical needs. Here, we present materials, device structures and fabrication procedures for bioresorbable pressure sensors with lifetimes exceeding those of previous reports by at least tenfold. We demonstrate measurement accuracies that compare favourably to those of the most sophisticated clinical standards for non-resorbable devices by monitoring intracranial pressures in rats for 25 days. Assessments of the biodistribution of the constituent materials, complete blood counts, blood chemistry and magnetic resonance imaging compatibility confirm the biodegradability and clinical utility of the device. Our findings establish routes for the design and fabrication of bioresorbable pressure monitors that meet requirements for clinical use.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNature biomedical engineering
Issue number1
Publication statusPublished - 2019 Jan 1

Bibliographical note

Funding Information:
J.S. thanks G. Mensing and J. Maduzia at the Micro-Nano-Mechanical Systems Cleanroom (University of Illinois at Urbana–Champaign) for assistance with process development. J.S. acknowledges support from True Phantom Solutions Inc. with the preparation of brain phantoms for MRI compatibility tests. Y.X. acknowledges support from the Ryan Fellowship and the Northwestern University International Institute for Nanotechnology. L.T. acknowledges support from a Beckman Institute Postdoctoral Fellowship at UIUC. I.K. acknowledges support from Cancer Center Support grant no. P30 CA060553 (National Cancer Institute) awarded to the Robert H. Lurie Comprehensive Cancer Center. K.J.Y. acknowledges support from the National Research Foundation of Korea (grant nos. NRF-2017M1A2A2048880 and NRF-2018M3A7B4071109) and Yonsei University Future-leading Research Initiative of 2017 (grant no. RMS2 2018-22-0028). Y.H. acknowledges support from the NSF (grant nos. 1400169, 1534120 and 1635443).

Publisher Copyright:
© 2018, The Author(s), under exclusive licence to Springer Nature Limited.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications


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