Abstract
During the last several years, a variety of degradable polymeric materials and medical devices have been developed, and their biological safety evaluation has evolved from screening assays. However, the clinical application of these materials and medical devices is still a critical issue due to the host responses resulting from inflammatory reactions and foreign-body response in their presence or their degraded toxic components in the body. Therefore, every degradable polymeric material and medical device used in biomedical applications needs to be screened for its biological safety. This chapter focuses on the biological response following implantation of degradable biomaterials and some methods for biological safety evaluation of degradable biomaterials recommended by the International Organization for Standardization (ISO) 10993 standard and US Food and Drug Administration (FDA) agency.
| Original language | English |
|---|---|
| Title of host publication | Degradation of Implant Materials |
| Publisher | Springer New York |
| Pages | 463-479 |
| Number of pages | 17 |
| Volume | 9781461439424 |
| ISBN (Electronic) | 9781461439424 |
| ISBN (Print) | 1461439418, 9781461439417 |
| DOIs | |
| Publication status | Published - 2012 Jul 1 |
Bibliographical note
Publisher Copyright:© 2012 Springer Science+Business Media New York. All rights are reserved.
All Science Journal Classification (ASJC) codes
- Engineering(all)
- Materials Science(all)