Biological evaluation of micro-nano patterned implant formed by anodic oxidation

Seung Kyun Moon, Jae Sung Kwon, Soo Hyuk Uhm, Eun Jung Lee, Hee Jin Gu, Tae Gwan Eom, Kyoung Nam Kim

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10 Citations (Scopus)


The studies have been carried out on dental implant system to shorten the healing period through modifying implant surface. Nano-patterned surface has been attempted to promote cell differentiation of osteoblast-like cells. Therefore, the purpose of this study was to develop dental implant surface with combined micro- and nano-patterned (MNP) surface and evaluate biological properties of it for dental implant application. The MNP implants were fabricated on the sandblasted with large grit and acid etched titanium (ASTM grade 4) implants (TSIII SA®, Osstem, 3.5 × 5 mm) using anodic oxidation. The nanostructures were uniformly formed on the implant surface. The mean pore sizes of nanostructure were about 30 nm and 70 nm. The biological evaluation showed that the MNP implants resulted in higher level of ALP activity, mineralization and osseointegration. Also, from the result of FE-SEM observation after removal torque test, it was evident that the morphology was preserved without change in nanostructure. The results were due to the nano-structure, which despite having relatively low mechanical properties, formed inside the micro structure and therefore exposed less during the torque force application. Such results showed that MNP surface can maintain shape of the nanotube even during the implant placement and such MNP implant will be suitable for dental implant.

Original languageEnglish
Pages (from-to)S183-S187
JournalCurrent Applied Physics
Issue numberSUPPL. 2
Publication statusPublished - 2014 Jul 24

Bibliographical note

Funding Information:
This work was supported by a grant from the National Research Foundation of Korea (NRF), which was funded by the Korean Government (MSIP) (NRF-2010-0027963).

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)


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