Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

Sujin Park; Eun Hye Kim; Jinwoo Kim; Seong Hwan Kim; Ikyon Kim

doi:10.1016/j.ejmech.2017.12.056

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

Sujin Park, Eun Hye Kim, Jinwoo Kim, Seong Hwan Kim, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.

Original language	English
Pages (from-to)	435-443
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	144
DOIs	https://doi.org/10.1016/j.ejmech.2017.12.056
Publication status	Published - 2018 Jan 20

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) ( 2017R1A2A2A05069364 ) (to I.K.) and the Korea Research Institute of Chemical Technology project grant ( KK1703-F02 ) (to S.K.).

Publisher Copyright:
© 2017 Elsevier Masson SAS

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2017.12.056

Cite this

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title = "Biological evaluation of indolizine-chalcone hybrids as new anticancer agents",

abstract = "A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.",

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AU - Kim, Jinwoo

AU - Kim, Seong Hwan

AU - Kim, Ikyon

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AB - A new chemical space was explored based on an indolizine-chalcone hybrid, which was readily accessible by base-mediated aldol condensation of indolizine bearing a 7-acetyl group with various (hetero)aromatic aldehydes. Their anticancer effect was evaluated, revealing that indolizine-chalcone hybrids with 3,5-dimethoxyphenyl group (4h) or the halogen at the meta position (4j and 4l) could have the potential to induce the caspase-dependent apoptosis of human lymphoma cells.

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Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

Abstract

Bibliographical note

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