Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives

Jae Min Song, Ki Duk Park, Kwang Hee Lee, Young Ho Byun, Ju Hee Park, Sung Han Kim, Jae Hong Kim, Baik Lin Seong

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63 Citations (Scopus)


Catechin derivatives with different alkyl chain length and aromatic ring substitutions at the 3-hydroxyl group were synthesized from epigallocatechin (EGC) and (+)-catechin (C) and their anti-influenza viral activity were evaluated in vitro and in ovo. Pronounced antiviral activity was observed for derivatives carrying moderate chain length (7-9 carbons) as compared to those with aromatic rings, whereas the 5′-hydroxyl group of the trihydroxy benzyl moiety did not significantly contribute to antiviral activity. The derivatives exerted inhibitory effects for all six influenza subtypes tested including three major types of currently circulating human influenza viruses (A/H1N1, A/H3N2 and B type), H2N2 and H9N2 avian influenza virus. The compounds strongly inhibited adsorption of the viruses on red blood cell (RBC). They also restricted the growth of avian influenza virus in ovo with minimum inhibition concentration (MIC) of 5-10 μM far exceeding the neuraminidase (NA) inhibitor oseltamivir or M2 proton channel inhibitor amantadine. The antiviral activity appears to be mediated by interaction with hemagglutinin (HA)/viral membrane rendering HA less fusogenic at the initial stage of infection. The broad spectrum activity against various subtypes of influenza viruses may complement the limitations of current antivirals and contribute for managing potentially emerging influenza pandemic. The structure-activity data of catechin derivatives may usefully guideline future research endeavors for applying green tea catechins as alternative anti-viral agents.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalAntiviral Research
Issue number2
Publication statusPublished - 2007 Nov

Bibliographical note

Funding Information:
We thank Dr. Sang Jun Lee in Amore-Pacific Co., Korea, for the supply of purified catechins during the initial phase of this work. This work was supported, in part, by the Chemical & Biological Terrorism Research Fund from the Ministry of Commerce, Industry and Energy (MOCIE) and Nanobiotechnology Research Initiatives (M10510000016-06N1000-01610) from the Ministry of Science and Technology (MOST) of the Korean Government.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Virology


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