Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

Rajkumar Patel; Madhumita Patel; Sung Hoon Ahn; Yong Kiel Sung; Hyung Keun Lee; Jong Hak Kim; Jung Suk Sung

doi:10.1016/j.msec.2012.12.097

Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

Rajkumar Patel, Madhumita Patel, Sung Hoon Ahn, Yong Kiel Sung, Hyung Keun Lee, Jong Hak Kim, Jung Suk Sung

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

Original language	English
Pages (from-to)	1662-1670
Number of pages	9
Journal	Materials Science and Engineering C
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2012.12.097
Publication status	Published - 2013 Apr 1

Bibliographical note

Funding Information:
We acknowledge the financial support of a National Research Foundation (NRF) grant funded by the Korean government (MEST) through the Core Research Program ( 2012R1A2A2A02011268 ), the Korea CCS R&D Center and the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Ministry of Knowledge Economy ( 20122010100040 ).

All Science Journal Classification (ASJC) codes

Bioengineering
Biomaterials

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10.1016/j.msec.2012.12.097

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title = "Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers",

abstract = "Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.",

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note = "Funding Information: We acknowledge the financial support of a National Research Foundation (NRF) grant funded by the Korean government (MEST) through the Core Research Program ( 2012R1A2A2A02011268 ), the Korea CCS R&D Center and the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Ministry of Knowledge Economy ( 20122010100040 ).",

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AU - Patel, Rajkumar

AU - Patel, Madhumita

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AU - Sung, Yong Kiel

AU - Lee, Hyung Keun

AU - Kim, Jong Hak

AU - Sung, Jung Suk

N1 - Funding Information: We acknowledge the financial support of a National Research Foundation (NRF) grant funded by the Korean government (MEST) through the Core Research Program ( 2012R1A2A2A02011268 ), the Korea CCS R&D Center and the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Ministry of Knowledge Economy ( 20122010100040 ).

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

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Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

Abstract

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