Bio-implant as a novel restoration for tooth loss

Dong Joon Lee, Jong Min Lee, Eun Jung Kim, Takashi Takata, Yoshihiro Abiko, Teruo Okano, David W. Green, Masaki Shimono, Han Sung Jung

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a "bio-implant" that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.

Original languageEnglish
Article number7414
JournalScientific reports
Issue number1
Publication statusPublished - 2017 Dec 1

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© 2017 The Author(s).

All Science Journal Classification (ASJC) codes

  • General


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