Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang, Vahid Serpooshan, Viola B. Morris, Nazish Sayed, Gaspard Pardon, Oscar J. Abilez, Karina H. Nakayama, Beth L. Pruitt, Sean M. Wu, Young sup Yoon, Jianyi Zhang, Joseph C. Wu

Research output: Contribution to journalComment/debatepeer-review

59 Citations (Scopus)

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

Original languageEnglish
Article number199
JournalCommunications Biology
Volume1
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

Bibliographical note

Publisher Copyright:
© 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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