Benzimidazole-based receptor for Zn 2+ recognition in a biological system: A chemosensor operated by retarding the excited state proton transfer

Min Joung Kim; Kamalpreet Kaur; Narinder Singh; Doo Ok Jang

doi:10.1016/j.tet.2012.04.097

Benzimidazole-based receptor for Zn ²⁺ recognition in a biological system: A chemosensor operated by retarding the excited state proton transfer

Min Joung Kim, Kamalpreet Kaur, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A new benzimidazole-based receptor was developed with potential functional groups for excited state proton transfer (ESPT) through keto-enol tautomerism. The enol form of the receptor selectively recognizes Zn ²⁺, allowing it to be used as a ratiometric fluorescence sensor in DMSO/CH ₃CN (1:9, v/v). The binding event triggers a blue-shifted band through the modulation of charge transfer transitions. The sensor is applicable for recognizing Zn ²⁺ in the cytoplasm of Saccharomyces cerevisiae.

Original language	English
Pages (from-to)	5429-5433
Number of pages	5
Journal	Tetrahedron
Volume	68
Issue number	27-28
DOIs	https://doi.org/10.1016/j.tet.2012.04.097
Publication status	Published - 2012 Jul 8

Bibliographical note

Funding Information:
This work was supported by the India-Korea Joint Program of Cooperation in Science &Technology ( 2011-0027710 ) and by an ISIRD project.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tet.2012.04.097

Cite this

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title = "Benzimidazole-based receptor for Zn 2+ recognition in a biological system: A chemosensor operated by retarding the excited state proton transfer",

abstract = "A new benzimidazole-based receptor was developed with potential functional groups for excited state proton transfer (ESPT) through keto-enol tautomerism. The enol form of the receptor selectively recognizes Zn 2+, allowing it to be used as a ratiometric fluorescence sensor in DMSO/CH 3CN (1:9, v/v). The binding event triggers a blue-shifted band through the modulation of charge transfer transitions. The sensor is applicable for recognizing Zn 2+ in the cytoplasm of Saccharomyces cerevisiae.",

author = "Kim, {Min Joung} and Kamalpreet Kaur and Narinder Singh and Jang, {Doo Ok}",

note = "Funding Information: This work was supported by the India-Korea Joint Program of Cooperation in Science &Technology ( 2011-0027710 ) and by an ISIRD project. ",

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AU - Kim, Min Joung

AU - Kaur, Kamalpreet

AU - Singh, Narinder

AU - Jang, Doo Ok

N1 - Funding Information: This work was supported by the India-Korea Joint Program of Cooperation in Science &Technology ( 2011-0027710 ) and by an ISIRD project.

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