Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome

Ju Youn Kim, Sung Hwan Kim, Sung Su Kim, Ki Hong Lee, Hyung Wook Park, Jeong Gwan Cho, Jae Sun Uhm, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee, Seung Jung Park, Young Keun On, June Soo Kim, Hong Euy Lim, Jaemin Shim, Jong Il Choi, Sang Weon Park, Young Hoon Kim, Woo Seok Lee, Jun KimGi Byoun Nam, Kee Joon Choi, You Ho Kim, Yong Seog Oh, Man Young Lee, Tai Ho Rho

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. Methods and results: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3%]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6%) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2% in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7%) had an episode of appropriate ICD therapy afterwards. Conclusions: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalInternational Journal of Cardiology
Issue number1
Publication statusPublished - 2015 May 6

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome'. Together they form a unique fingerprint.

Cite this