BCl3-promoted synthesis of benzofurans

Ikyon Kim; Sei Hee Lee; Sunkyung Lee

doi:10.1016/j.tetlet.2008.09.034

BCl₃-promoted synthesis of benzofurans

Ikyon Kim, Sei Hee Lee, Sunkyung Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Lewis acidic nature of boron trichloride (BCl₃) to coordinate to the carbonyl functionality was exploited for the synthesis of benzofurans via dehydrative cyclization. This mild and efficient procedure allowed for facile access to a number of highly substituted benzofurans in a regioselective manner. The structural requirement for the successful cyclodehydration was examined in the cases, where competitive demethylation could occur.

Original language	English
Pages (from-to)	6579-6584
Number of pages	6
Journal	Tetrahedron Letters
Volume	49
Issue number	46
DOIs	https://doi.org/10.1016/j.tetlet.2008.09.034
Publication status	Published - 2008 Nov 10

Bibliographical note

Funding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for supporting this work.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2008.09.034

Cite this

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abstract = "Lewis acidic nature of boron trichloride (BCl3) to coordinate to the carbonyl functionality was exploited for the synthesis of benzofurans via dehydrative cyclization. This mild and efficient procedure allowed for facile access to a number of highly substituted benzofurans in a regioselective manner. The structural requirement for the successful cyclodehydration was examined in the cases, where competitive demethylation could occur.",

author = "Ikyon Kim and Lee, {Sei Hee} and Sunkyung Lee",

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