Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

Yong Suk Oh; Jae Hwan Kim; Zhaoqian Xie; Seokjoo Cho; Hyeonseok Han; Sung Woo Jeon; Minsu Park; Myeong Namkoong; Raudel Avila; Zhen Song; Sung Uk Lee; Kabseok Ko; Jungyup Lee; Je Sang Lee; Weon Gi Min; Byeong Ju Lee; Myungwoo Choi; Ha Uk Chung; Jongwon Kim; Mengdi Han; Jahyun Koo; Yeon Sik Choi; Sung Soo Kwak; Sung Bong Kim; Jeonghyun Kim; Jungil Choi; Chang Mo Kang; Jong Uk Kim; Kyeongha Kwon; Sang Min Won; Janice Mihyun Baek; Yujin Lee; So Young Kim; Wei Lu; Abraham Vazquez-Guardado; Hyoyoung Jeong; Hanjun Ryu; Geumbee Lee; Kyuyoung Kim; Seunghwan Kim; Min Seong Kim; Jungrak Choi; Dong Yun Choi; Quansan Yang; Hangbo Zhao; Wubin Bai; Hokyung Jang; Yongjoon Yu; Jaeman Lim; Xu Guo; Bong Hoon Kim; Seokwoo Jeon; Charles Davies; Anthony Banks; Hyung Jin Sung; Yonggang Huang; Inkyu Park; John A. Rogers

doi:10.1038/s41467-021-25324-w

Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

Yong Suk Oh, Jae Hwan Kim, Zhaoqian Xie, Seokjoo Cho, Hyeonseok Han, Sung Woo Jeon, Minsu Park, Myeong Namkoong, Raudel Avila, Zhen Song, Sung Uk Lee, Kabseok Ko, Jungyup Lee, Je Sang Lee, Weon Gi Min, Byeong Ju Lee, Myungwoo Choi, Ha Uk Chung, Jongwon Kim, Mengdi HanJahyun Koo, Yeon Sik Choi, Sung Soo Kwak, Sung Bong Kim, Jeonghyun Kim, Jungil Choi, Chang Mo Kang, Jong Uk Kim, Kyeongha Kwon, Sang Min Won, Janice Mihyun Baek, Yujin Lee, So Young Kim, Wei Lu, Abraham Vazquez-Guardado, Hyoyoung Jeong, Hanjun Ryu, Geumbee Lee, Kyuyoung Kim, Seunghwan Kim, Min Seong Kim, Jungrak Choi, Dong Yun Choi, Quansan Yang, Hangbo Zhao, Wubin Bai, Hokyung Jang, Yongjoon Yu, Jaeman Lim, Xu Guo, Bong Hoon Kim, Seokwoo Jeon, Charles Davies, Anthony Banks, Hyung Jin Sung, Yonggang Huang, Inkyu Park, John A. Rogers

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.

Original language	English
Article number	5008
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-25324-w
Publication status	Published - 2021 Dec 1

Bibliographical note

Funding Information:
The materials and device-engineering aspects of the research were supported by the Center for Bio-Integrated Electronics at Northwestern University. This work made use of the NUFAB facility of Northwestern University’s NUANCE Center. Y.S.O is supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2020R1I1A1A0107489711). Y.S.O, S.C., H.H., K.K., S.K., M.S.K., J.C., and I.P. are supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) (no. 2018R1A2B200491013). H.J.S. is supported by grant from the National Research Foundation of Korea (NRF) (no. 2020 R1A2C2008106). J. Koo acknowledges the support from the Korea Medical Device Development Fund (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0137). Z.X. acknowledges the support from the National Natural Science Foundation of China (Grant No. 12072057), LiaoNing Revitalization Talents Program (Grant No. XLYC2007196), and Fundamental Research Funds for the Central Universities (Grant No. DUT20RC(3)032). Y.H. acknowledges support from NSF(CMMI1635443).

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

Physics and Astronomy(all)
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1038/s41467-021-25324-w

Cite this

Oh, Y. S., Kim, J. H., Xie, Z., Cho, S., Han, H., Jeon, S. W., Park, M., Namkoong, M., Avila, R., Song, Z., Lee, S. U., Ko, K., Lee, J., Lee, J. S., Min, W. G., Lee, B. J., Choi, M., Chung, H. U., Kim, J., ... Rogers, J. A. (2021). Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries. Nature communications, 12(1), Article 5008. https://doi.org/10.1038/s41467-021-25324-w

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title = "Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries",

abstract = "Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.",

author = "Oh, {Yong Suk} and Kim, {Jae Hwan} and Zhaoqian Xie and Seokjoo Cho and Hyeonseok Han and Jeon, {Sung Woo} and Minsu Park and Myeong Namkoong and Raudel Avila and Zhen Song and Lee, {Sung Uk} and Kabseok Ko and Jungyup Lee and Lee, {Je Sang} and Min, {Weon Gi} and Lee, {Byeong Ju} and Myungwoo Choi and Chung, {Ha Uk} and Jongwon Kim and Mengdi Han and Jahyun Koo and Choi, {Yeon Sik} and Kwak, {Sung Soo} and Kim, {Sung Bong} and Jeonghyun Kim and Jungil Choi and Kang, {Chang Mo} and Kim, {Jong Uk} and Kyeongha Kwon and Won, {Sang Min} and Baek, {Janice Mihyun} and Yujin Lee and Kim, {So Young} and Wei Lu and Abraham Vazquez-Guardado and Hyoyoung Jeong and Hanjun Ryu and Geumbee Lee and Kyuyoung Kim and Seunghwan Kim and Kim, {Min Seong} and Jungrak Choi and Choi, {Dong Yun} and Quansan Yang and Hangbo Zhao and Wubin Bai and Hokyung Jang and Yongjoon Yu and Jaeman Lim and Xu Guo and Kim, {Bong Hoon} and Seokwoo Jeon and Charles Davies and Anthony Banks and Sung, {Hyung Jin} and Yonggang Huang and Inkyu Park and Rogers, {John A.}",

note = "Funding Information: The materials and device-engineering aspects of the research were supported by the Center for Bio-Integrated Electronics at Northwestern University. This work made use of the NUFAB facility of Northwestern University{\textquoteright}s NUANCE Center. Y.S.O is supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2020R1I1A1A0107489711). Y.S.O, S.C., H.H., K.K., S.K., M.S.K., J.C., and I.P. are supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) (no. 2018R1A2B200491013). H.J.S. is supported by grant from the National Research Foundation of Korea (NRF) (no. 2020 R1A2C2008106). J. Koo acknowledges the support from the Korea Medical Device Development Fund (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0137). Z.X. acknowledges the support from the National Natural Science Foundation of China (Grant No. 12072057), LiaoNing Revitalization Talents Program (Grant No. XLYC2007196), and Fundamental Research Funds for the Central Universities (Grant No. DUT20RC(3)032). Y.H. acknowledges support from NSF(CMMI1635443). Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1038/s41467-021-25324-w",

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Oh, YS, Kim, JH, Xie, Z, Cho, S, Han, H, Jeon, SW, Park, M, Namkoong, M, Avila, R, Song, Z, Lee, SU, Ko, K, Lee, J, Lee, JS, Min, WG, Lee, BJ, Choi, M, Chung, HU, Kim, J, Han, M, Koo, J, Choi, YS, Kwak, SS, Kim, SB, Kim, J, Choi, J, Kang, CM, Kim, JU, Kwon, K, Won, SM, Baek, JM, Lee, Y, Kim, SY, Lu, W, Vazquez-Guardado, A, Jeong, H, Ryu, H, Lee, G, Kim, K, Kim, S, Kim, MS, Choi, J, Choi, DY, Yang, Q, Zhao, H, Bai, W, Jang, H, Yu, Y, Lim, J, Guo, X, Kim, BH, Jeon, S, Davies, C, Banks, A, Sung, HJ, Huang, Y, Park, I & Rogers, JA 2021, 'Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries', Nature communications, vol. 12, no. 1, 5008. https://doi.org/10.1038/s41467-021-25324-w

TY - JOUR

T1 - Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

AU - Oh, Yong Suk

AU - Kim, Jae Hwan

AU - Xie, Zhaoqian

AU - Cho, Seokjoo

AU - Han, Hyeonseok

AU - Jeon, Sung Woo

AU - Park, Minsu

AU - Namkoong, Myeong

AU - Avila, Raudel

AU - Song, Zhen

AU - Lee, Sung Uk

AU - Ko, Kabseok

AU - Lee, Jungyup

AU - Lee, Je Sang

AU - Min, Weon Gi

AU - Lee, Byeong Ju

AU - Choi, Myungwoo

AU - Chung, Ha Uk

AU - Kim, Jongwon

AU - Han, Mengdi

AU - Koo, Jahyun

AU - Choi, Yeon Sik

AU - Kwak, Sung Soo

AU - Kim, Sung Bong

AU - Kim, Jeonghyun

AU - Choi, Jungil

AU - Kang, Chang Mo

AU - Kim, Jong Uk

AU - Kwon, Kyeongha

AU - Won, Sang Min

AU - Baek, Janice Mihyun

AU - Lee, Yujin

AU - Kim, So Young

AU - Lu, Wei

AU - Vazquez-Guardado, Abraham

AU - Jeong, Hyoyoung

AU - Ryu, Hanjun

AU - Lee, Geumbee

AU - Kim, Kyuyoung

AU - Kim, Seunghwan

AU - Kim, Min Seong

AU - Choi, Jungrak

AU - Choi, Dong Yun

AU - Yang, Quansan

AU - Zhao, Hangbo

AU - Bai, Wubin

AU - Jang, Hokyung

AU - Yu, Yongjoon

AU - Lim, Jaeman

AU - Guo, Xu

AU - Kim, Bong Hoon

AU - Jeon, Seokwoo

AU - Davies, Charles

AU - Banks, Anthony

AU - Sung, Hyung Jin

AU - Huang, Yonggang

AU - Park, Inkyu

AU - Rogers, John A.

N1 - Funding Information: The materials and device-engineering aspects of the research were supported by the Center for Bio-Integrated Electronics at Northwestern University. This work made use of the NUFAB facility of Northwestern University’s NUANCE Center. Y.S.O is supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2020R1I1A1A0107489711). Y.S.O, S.C., H.H., K.K., S.K., M.S.K., J.C., and I.P. are supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) (no. 2018R1A2B200491013). H.J.S. is supported by grant from the National Research Foundation of Korea (NRF) (no. 2020 R1A2C2008106). J. Koo acknowledges the support from the Korea Medical Device Development Fund (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (KMDF_PR_20200901_0137). Z.X. acknowledges the support from the National Natural Science Foundation of China (Grant No. 12072057), LiaoNing Revitalization Talents Program (Grant No. XLYC2007196), and Fundamental Research Funds for the Central Universities (Grant No. DUT20RC(3)032). Y.H. acknowledges support from NSF(CMMI1635443). Publisher Copyright: © 2021, The Author(s).

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.

AB - Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential for pressure injuries in hospitalized patients or in individuals confined to the bed. This paper introduces a soft, skin-mountable class of sensor system for this purpose. The design includes a pressure-responsive element based on membrane deflection and a battery-free, wireless mode of operation capable of multi-site measurements at strategic locations across the body. Such devices yield continuous, simultaneous readings of pressure and temperature in a sequential readout scheme from a pair of primary antennas mounted under the bedding and connected to a wireless reader and a multiplexer located at the bedside. Experimental evaluation of the sensor and the complete system includes benchtop measurements and numerical simulations of the key features. Clinical trials involving two hemiplegic patients and a tetraplegic patient demonstrate the feasibility, functionality and long-term stability of this technology in operating hospital settings.

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DO - 10.1038/s41467-021-25324-w

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VL - 12

JO - Nature communications

JF - Nature communications

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Battery-free, wireless soft sensors for continuous multi-site measurements of pressure and temperature from patients at risk for pressure injuries

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