Basic principles of hydrogel-based tissue transformation technologies and their applications

Seo Woo Choi, Webster Guan, Kwanghun Chung

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Emerging tissue transformation technologies provide an unprecedented opportunity to investigate system-level molecular and anatomical features in situ. Hydrogel-based methods engineer physicochemical tissue properties to render intact organs optically transparent and size and shape adjustable while preserving biomolecules at their physiological locations. When combined with advanced molecular tools, labeling, and imaging techniques, tissue transformation enables three-dimensional (3D) mapping of molecules, cells, and their interrelationships at increasing speeds and resolutions. In this review, we discuss the basic engineering principles of tissue transformation and labeling techniques as well as their broad applications, current challenges, and future potential.

Original languageEnglish
Pages (from-to)4115-4136
Number of pages22
Issue number16
Publication statusPublished - 2021 Aug 5

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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