Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Sze Yinn Wong; Qing Li; Jovana Veselinovic; Byeong Su Kim; Alexander M. Klibanov; Paula T. Hammond

doi:10.1016/j.biomaterials.2010.01.119

Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Sze Yinn Wong, Qing Li, Jovana Veselinovic, Byeong Su Kim, Alexander M. Klibanov, Paula T. Hammond

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

Original language	English
Pages (from-to)	4079-4087
Number of pages	9
Journal	Biomaterials
Volume	31
Issue number	14
DOIs	https://doi.org/10.1016/j.biomaterials.2010.01.119
Publication status	Published - 2010 May

Bibliographical note

Funding Information:
We thank members of the Chen and Klibanov laboratories at MIT, especially Bryan Hsu, for help with handling influenza virus and synthesis of the polycations. We also thank Jinkee Hong, Steve Kooi, and Yunhong Min for help with SEM, FT-IR, and AFM respectively. This work was funded by the United States Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology.

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2010.01.119

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title = "Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions",

abstract = "In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.",

author = "Wong, {Sze Yinn} and Qing Li and Jovana Veselinovic and Kim, {Byeong Su} and Klibanov, {Alexander M.} and Hammond, {Paula T.}",

note = "Funding Information: We thank members of the Chen and Klibanov laboratories at MIT, especially Bryan Hsu, for help with handling influenza virus and synthesis of the polycations. We also thank Jinkee Hong, Steve Kooi, and Yunhong Min for help with SEM, FT-IR, and AFM respectively. This work was funded by the United States Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology. ",

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AU - Veselinovic, Jovana

AU - Kim, Byeong Su

AU - Klibanov, Alexander M.

AU - Hammond, Paula T.

N1 - Funding Information: We thank members of the Chen and Klibanov laboratories at MIT, especially Bryan Hsu, for help with handling influenza virus and synthesis of the polycations. We also thank Jinkee Hong, Steve Kooi, and Yunhong Min for help with SEM, FT-IR, and AFM respectively. This work was funded by the United States Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology.

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N2 - In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

AB - In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

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Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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