Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes

Youn Hee Nam, Isabel Rodriguez, Seo Yeon Jeong, Thu Nguyen Minh Pham, Wanlapa Nuankaew, Yun Hee Kim, Rodrigo Castañeda, Seo Yule Jeong, Min Seon Park, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, Seung Hyun Kim, In Seok Moon, Se Young Choung, Bin Na Hong, Kwang Won Jeong, Tong Ho Kang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

Original languageEnglish
Article number113
Issue number1
Publication statusPublished - 2019 Jan

Bibliographical note

Funding Information:
Funding: This work was supported by the Technology Innovation Program (10080691, Development of an individual approval health functional food and global product; protection of hearing loss and improvement of auditory function for the people with light to moderate hearing loss (26–55 dB of pure tone audiometry threshold) using avocado fraction) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea).

Publisher Copyright:
© 2019, MDPI AG. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics


Dive into the research topics of 'Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes'. Together they form a unique fingerprint.

Cite this