Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy

Seung Jun Oh; Dae Hyuk Moon; Hyun Joon Ha; Seong Wook Park; Myeong Ki Hong; Seung Jung Park; Tae Hyun Choi; Sang Moo Lim; Chang Woon Choi; F. F. Knapp; Hee Kyung Lee

doi:10.1016/S0969-8043(00)00279-7

Automation of the synthesis of highly concentrated ¹⁸⁸Re-MAG₃ for intracoronary radiation therapy

Seung Jun Oh, Dae Hyuk Moon, Hyun Joon Ha, Seong Wook Park, Myeong Ki Hong, Seung Jung Park, Tae Hyun Choi, Sang Moo Lim, Chang Woon Choi, F. F. Knapp, Hee Kyung Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated ¹⁸⁸Re-MAG₃. Routine production of ¹⁸⁸Re-MAG₃ for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. ¹⁸⁸Re-MAG₃ was prepared with a commercial kit and reducing agents, purified and concentrated by C₁₈ Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.

Original language	English
Pages (from-to)	419-427
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/S0969-8043(00)00279-7
Publication status	Published - 2001

Bibliographical note

Funding Information:
This study was supported by grant No. 1999-2-206-001-3 from the interdisciplinary research program of the KOSEF.

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/S0969-8043(00)00279-7

Cite this

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title = "Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy",

abstract = "We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.",

author = "Oh, {Seung Jun} and Moon, {Dae Hyuk} and Ha, {Hyun Joon} and Park, {Seong Wook} and Hong, {Myeong Ki} and Park, {Seung Jung} and Choi, {Tae Hyun} and Lim, {Sang Moo} and Choi, {Chang Woon} and Knapp, {F. F.} and Lee, {Hee Kyung}",

note = "Funding Information: This study was supported by grant No. 1999-2-206-001-3 from the interdisciplinary research program of the KOSEF. ",

year = "2001",

doi = "10.1016/S0969-8043(00)00279-7",

language = "English",

volume = "54",

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T1 - Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy

AU - Oh, Seung Jun

AU - Moon, Dae Hyuk

AU - Ha, Hyun Joon

AU - Park, Seong Wook

AU - Hong, Myeong Ki

AU - Park, Seung Jung

AU - Choi, Tae Hyun

AU - Lim, Sang Moo

AU - Choi, Chang Woon

AU - Knapp, F. F.

AU - Lee, Hee Kyung

N1 - Funding Information: This study was supported by grant No. 1999-2-206-001-3 from the interdisciplinary research program of the KOSEF.

PY - 2001

Y1 - 2001

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AB - We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.

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