Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy

Seung Jun Oh; Dae Hyuk Moon; Won Woo Lee; Seong Wook Park; Myeong Ki Hong; Seung Jung Park; Dong Ik Shin; Hee Kyung Lee

doi:10.1016/S0969-8043(03)00170-2

Automated preparation of ¹⁸⁸Re-labeled radiopharmaceuticals for endovascular radiation therapy

Seung Jun Oh, Dae Hyuk Moon, Won Woo Lee, Seong Wook Park, Myeong Ki Hong, Seung Jung Park, Dong Ik Shin, Hee Kyung Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We have developed an automated system for the preparation of highly concentrated ¹⁸⁸Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG₃). The three procedural steps include concentration of ¹⁸⁸Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted ¹⁸⁸Re-perrhenate of 15GBq/18ml from 37GBq ¹⁸⁸W/¹⁸⁸Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for ¹⁸⁸Re-DTPA and MAG₃ at the oil bath temperatures of 95-97°C and 93-97°C, respectively.

Original language	English
Pages (from-to)	225-230
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/S0969-8043(03)00170-2
Publication status	Published - 2003 Oct

Bibliographical note

Funding Information:
This study was supported by Korea Institute of Science & Technology Evaluation and Planning (KISTEP) and Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program.

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/S0969-8043(03)00170-2

Cite this

@article{120586577fd24da29aa2873e47478bc2,

title = "Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy",

abstract = "We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15GBq/18ml from 37GBq 188W/188Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97°C and 93-97°C, respectively.",

author = "Oh, {Seung Jun} and Moon, {Dae Hyuk} and Lee, {Won Woo} and Park, {Seong Wook} and Hong, {Myeong Ki} and Park, {Seung Jung} and Shin, {Dong Ik} and Lee, {Hee Kyung}",

note = "Funding Information: This study was supported by Korea Institute of Science & Technology Evaluation and Planning (KISTEP) and Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program.",

year = "2003",

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doi = "10.1016/S0969-8043(03)00170-2",

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T1 - Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy

AU - Oh, Seung Jun

AU - Moon, Dae Hyuk

AU - Lee, Won Woo

AU - Park, Seong Wook

AU - Hong, Myeong Ki

AU - Park, Seung Jung

AU - Shin, Dong Ik

AU - Lee, Hee Kyung

N1 - Funding Information: This study was supported by Korea Institute of Science & Technology Evaluation and Planning (KISTEP) and Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program.

PY - 2003/10

Y1 - 2003/10

N2 - We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15GBq/18ml from 37GBq 188W/188Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97°C and 93-97°C, respectively.

AB - We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15GBq/18ml from 37GBq 188W/188Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97°C and 93-97°C, respectively.

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