Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy

Seung Jun Oh, Dae Hyuk Moon, Won Woo Lee, Seong Wook Park, Myeong Ki Hong, Seung Jung Park, Dong Ik Shin, Hee Kyung Lee

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15GBq/18ml from 37GBq 188W/188Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97°C and 93-97°C, respectively.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalApplied Radiation and Isotopes
Issue number4
Publication statusPublished - 2003 Oct

Bibliographical note

Funding Information:
This study was supported by Korea Institute of Science & Technology Evaluation and Planning (KISTEP) and Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program.

All Science Journal Classification (ASJC) codes

  • Radiation


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