Autoimmune hepatic failure following acute hepatitis a is accompanied by inflammatory conversion of regulatory T cells

Galam Leem, Beom Kyung Kim, Eui Cheol Shin, Jun Yong Park

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.

Original languageEnglish
Pages (from-to)100-102
Number of pages3
JournalYonsei medical journal
Volume61
Issue number1
DOIs
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© Yonsei University College of Medicine 2020.

All Science Journal Classification (ASJC) codes

  • General Medicine

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