Asymmetric total synthesis of ent-Tetrahydrolipstatin from an epoxy alkenol

Hyemi Kim, Kyeonghwan Choi, Jinsung Tae

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A highly efficient asymmetric total synthesis of ent-tetrahydrolipstatin (THL) was accomplished from the known epoxy alkenol. The β-lactone portion of THL was synthesized by the epoxide opening with cyanide and stereoselective enolate alkylation method. The side chain was introduced by cross metathesis of the alkene part with 1-decene. Coupling with a protected leucine completed the synthesis of ent-tetrahydrolipstatin.

Original languageEnglish
Pages (from-to)1832-1834
Number of pages3
Issue number12
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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