Asymmetric total synthesis of (+)-brefeldin A: Intramolecular epoxide-opening/RCM strategy

Myung Yeol Kim; Hyemi Kim; Jinsung Tae

doi:10.1055/s-0029-1216723

Asymmetric total synthesis of (+)-brefeldin A: Intramolecular epoxide-opening/RCM strategy

Myung Yeol Kim, Hyemi Kim, Jinsung Tae

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A highly efficient asymmetric total synthesis of (+)-brefeldin A was accomplished by using intramolecular epoxide opening of an epoxy allylsilane and RCM reaction for the constructions of the cyclopentane and macrocyclic lactone rings of (+)-brefeldin A, respectively.

Original language	English
Pages (from-to)	1303-1306
Number of pages	4
Journal	Synlett
Issue number	8
DOIs	https://doi.org/10.1055/s-0029-1216723
Publication status	Published - 2009 May

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "Asymmetric total synthesis of (+)-brefeldin A: Intramolecular epoxide-opening/RCM strategy",

abstract = "A highly efficient asymmetric total synthesis of (+)-brefeldin A was accomplished by using intramolecular epoxide opening of an epoxy allylsilane and RCM reaction for the constructions of the cyclopentane and macrocyclic lactone rings of (+)-brefeldin A, respectively.",

author = "Kim, {Myung Yeol} and Hyemi Kim and Jinsung Tae",

year = "2009",

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doi = "10.1055/s-0029-1216723",

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journal = "Synlett",

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AU - Kim, Hyemi

AU - Tae, Jinsung

PY - 2009/5

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AB - A highly efficient asymmetric total synthesis of (+)-brefeldin A was accomplished by using intramolecular epoxide opening of an epoxy allylsilane and RCM reaction for the constructions of the cyclopentane and macrocyclic lactone rings of (+)-brefeldin A, respectively.

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JO - Synlett

JF - Synlett

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Asymmetric total synthesis of (+)-brefeldin A: Intramolecular epoxide-opening/RCM strategy

Abstract

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