Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye Ja Lee, Jae Heon Kang, Kyung Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objectives: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. Methods: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5±0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards. Results: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. Conclusion: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalOsong Public Health and Research Perspectives
Issue number5
Publication statusPublished - 2014

Bibliographical note

Publisher Copyright:
© 2014.

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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