Association of polyfluoroalkyl chemical exposure with serum lipids in children

Xiao Wen Zeng; Zhengmin Qian; Brett Emo; Michael Vaughn; Jia Bao; Xiao Di Qin; Yu Zhu; Jie Li; Yungling Leo Lee; Guang Hui Dong

doi:10.1016/j.scitotenv.2015.01.042

Association of polyfluoroalkyl chemical exposure with serum lipids in children

Xiao Wen Zeng, Zhengmin Qian, Brett Emo, Michael Vaughn, Jia Bao, Xiao Di Qin, Yu Zhu, Jie Li, Yungling Leo Lee, Guang Hui Dong

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

Original language	English
Pages (from-to)	364-370
Number of pages	7
Journal	Science of the Total Environment
Volume	512-513
DOIs	https://doi.org/10.1016/j.scitotenv.2015.01.042
Publication status	Published - 2015 Apr 5

Bibliographical note

Funding Information:
This study was supported by grant no. 81172630 and no. 81472936 from the National Natural Science Foundation of China , grant no. 98-2314-B-002-138-MY3 from the National Science Council in Taiwan , and grant no. 201202264 from the Liaoning Province Science and Technology Foundation . The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication.

Publisher Copyright:
© 2015 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

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10.1016/j.scitotenv.2015.01.042

Cite this

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title = "Association of polyfluoroalkyl chemical exposure with serum lipids in children",

abstract = "Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.",

author = "Zeng, {Xiao Wen} and Zhengmin Qian and Brett Emo and Michael Vaughn and Jia Bao and Qin, {Xiao Di} and Yu Zhu and Jie Li and Lee, {Yungling Leo} and Dong, {Guang Hui}",

note = "Funding Information: This study was supported by grant no. 81172630 and no. 81472936 from the National Natural Science Foundation of China , grant no. 98-2314-B-002-138-MY3 from the National Science Council in Taiwan , and grant no. 201202264 from the Liaoning Province Science and Technology Foundation . The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

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doi = "10.1016/j.scitotenv.2015.01.042",

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T1 - Association of polyfluoroalkyl chemical exposure with serum lipids in children

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin

AU - Emo, Brett

AU - Vaughn, Michael

AU - Bao, Jia

AU - Qin, Xiao Di

AU - Zhu, Yu

AU - Li, Jie

AU - Lee, Yungling Leo

AU - Dong, Guang Hui

N1 - Funding Information: This study was supported by grant no. 81172630 and no. 81472936 from the National Natural Science Foundation of China , grant no. 98-2314-B-002-138-MY3 from the National Science Council in Taiwan , and grant no. 201202264 from the Liaoning Province Science and Technology Foundation . The views expressed in this article are those of the authors and do not necessarily represent those of the funding source. The funding source had no role in the design or analysis of the study publication. Publisher Copyright: © 2015 Elsevier B.V.

PY - 2015/4/5

Y1 - 2015/4/5

N2 - Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

AB - Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

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ER -

Association of polyfluoroalkyl chemical exposure with serum lipids in children

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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