Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

O. Y. Kim; H. H. Lim; M. J. Lee; J. Y. Kim; J. H. Lee

doi:10.1016/j.numecd.2011.06.006

Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

O. Y. Kim, H. H. Lim, M. J. Lee, J. Y. Kim, J. H. Lee

Department of Food and Nutrition

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R²=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

Original language	English
Pages (from-to)	366-374
Number of pages	9
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.numecd.2011.06.006
Publication status	Published - 2013 Apr

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation, Ministry of Education, Science and Technology (2010-0011003, Mid-career Researcher Program: 2010-0015017, M10642120002-06N4212-00210), Republic of Korea.

Funding Information:
We thank the research volunteers who participated in this study. This work was supported by the National Research Foundation (Mid-career Researcher Program: 2010-0015017, 2010-0011003 , and M10642120002-06N4212-00210 ), Republic of Korea.

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.numecd.2011.06.006

Cite this

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title = "Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness",

abstract = "Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.",

author = "Kim, {O. Y.} and Lim, {H. H.} and Lee, {M. J.} and Kim, {J. Y.} and Lee, {J. H.}",

note = "Funding Information: This work was supported by the National Research Foundation, Ministry of Education, Science and Technology (2010-0011003, Mid-career Researcher Program: 2010-0015017, M10642120002-06N4212-00210), Republic of Korea. Funding Information: We thank the research volunteers who participated in this study. This work was supported by the National Research Foundation (Mid-career Researcher Program: 2010-0015017, 2010-0011003 , and M10642120002-06N4212-00210 ), Republic of Korea. ",

year = "2013",

month = apr,

doi = "10.1016/j.numecd.2011.06.006",

language = "English",

volume = "23",

pages = "366--374",

journal = "Nutrition, Metabolism and Cardiovascular Diseases",

issn = "0939-4753",

publisher = "Elsevier",

number = "4",

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T1 - Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

AU - Kim, O. Y.

AU - Lim, H. H.

AU - Lee, M. J.

AU - Kim, J. Y.

AU - Lee, J. H.

N1 - Funding Information: This work was supported by the National Research Foundation, Ministry of Education, Science and Technology (2010-0011003, Mid-career Researcher Program: 2010-0015017, M10642120002-06N4212-00210), Republic of Korea. Funding Information: We thank the research volunteers who participated in this study. This work was supported by the National Research Foundation (Mid-career Researcher Program: 2010-0015017, 2010-0011003 , and M10642120002-06N4212-00210 ), Republic of Korea.

PY - 2013/4

Y1 - 2013/4

N2 - Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

AB - Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

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Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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