TY - JOUR
T1 - Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
AU - Yamada, Yoshiji
AU - Nishida, Tamotsu
AU - Ichihara, Sahoko
AU - Sawabe, Motoji
AU - Fuku, Noriyuki
AU - Nishigaki, Yutaka
AU - Aoyagi, Yukitoshi
AU - Tanaka, Masashi
AU - Fujiwara, Yoshinori
AU - Yoshida, Hiroto
AU - Shinkai, Shoji
AU - Satoh, Kei
AU - Kato, Kimihiko
AU - Fujimaki, Tetsuo
AU - Yokoi, Kiyoshi
AU - Oguri, Mitsutoshi
AU - Yoshida, Tetsuro
AU - Watanabe, Sachiro
AU - Nozawa, Yoshinori
AU - Hasegawa, Aki
AU - Kojima, Toshio
AU - Han, Bok Ghee
AU - Ahn, Younjin
AU - Lee, Meehee
AU - Shin, Dong Jik
AU - Lee, Jong Ho
AU - Jang, Yangsoo
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (nos. 18209023 , 18018021 , and 19659149 to Y.Y.) and by a Research Grant from Mie Medical Valley Project (to Y.Y.).
PY - 2011/3
Y1 - 2011/3
N2 - Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.
AB - Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.
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U2 - 10.1016/j.atherosclerosis.2010.12.005
DO - 10.1016/j.atherosclerosis.2010.12.005
M3 - Article
C2 - 21211798
AN - SCOPUS:79952099987
SN - 0021-9150
VL - 215
SP - 145
EP - 152
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -