Abstract
OBJECTIVE: Coronary artery disease is caused by multiple genetic and environmental factors. The disease is also closely associated with cardiovascular conditions such as hypertension. In order to investigate any possible role of hypertension candidate genes in the disease development and progression, we examined the association of the polymorphisms of 31 hypertension candidate genes with coronary artery disease. METHODS: Genetic polymorphisms of 31 hypertension candidate genes were initially screened by resequencing DNA samples from 24 unrelated individuals in a Korean population. Association analysis was performed using 1284 unrelated Korean men, including 749 coronary artery disease subjects and 535 normal healthy controls. RESULTS: We identified a total of 409 single nucleotide polymorphisms including 40 nonsynonymous single nucleotide polymorphisms, 32 insertions/deletions and four microsatellites. Among 40 nonsynonymous single nucleotide polymorphisms, 29 were examined for an association with coronary artery disease. A significant association with coronary artery disease was observed in a polymorphism of the ADD1 gene (Gly460Trp; +29017G/T) (odds ratio 0.71-0.81; P = 0.01-0.04). The same polymorphism was also associated with the number of arteries with significant coronary artery stenosis in the coronary artery disease patients (P = 0.01) as well as the increase in systolic blood pressure (P = 0.02). CONCLUSIONS: The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 2413-2420 |
| Number of pages | 8 |
| Journal | Journal of hypertension |
| Volume | 25 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2007 Dec |
Bibliographical note
Funding Information:So far, cultural practices are mainly applied to control bacterial canker. use of disease resistant cultvars is one of the most viable options for cherry cultivation because the growers need not expend funds for extraneous control measures such as fungicides. according to Wimalajeewa et al. (1991), a spray schedule consisting of two autumn, one winter, and two pre-bloom spring sprays with copper hydroxide on apricot or bordeaux mixture on cherry was successful in reducing canker ( 67% reduction) and is recommended for control of bacterial canker. Even where fungicides must be used, resistance is a useful complementary control measure. a t the Pomology institute at Naoussa, Greece, a research programme was carried out on the selection of cherry genotypes (natural hybrids collected from different parts of Greece as part of a research project funded by the National agricultural Research Foundation for the collection of genetic materials) appropriate for Greek conditions. Thirty of these were recognised as the most promising genotypes based on their agronomic characteristics (productivity, fruit quality, etc) and some of them (genotypes with acceptable commercial traits) will possibly be released for commercial use in the near future. Because P. syringae is an important pathogen for cherry trees, as reported above, the benefits for commercial growers if one of the above genotypes had a level of resistance is easily understood. The purpose of this study was to evaluate the susceptibility of these genotypes to the bacterium P. s. pv syringae.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine