Association between striatal amyloid deposition and motor prognosis in Parkinson's disease

Mincheol Park, Hyun Joo Kim, Kyoungwon Baik, Han Kyu Na, Young gun Lee, So Hoon Yoon, Seong Ho Jeong, Seok Jong Chung, Hae Won Shin, Chul Hyoung Lyoo, Young H. Sohn, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: The co-occurrence of amyloid-β pathology in Parkinson's disease (PD) is common; however, the role of amyloid-β deposition in motor prognosis remains elusive. This study aimed to investigate the association between striatal amyloid deposition, motor complications and motor prognosis in patients with PD. Methods: Ninety-six patients with PD who underwent 18F florbetaben (FBB) positron emission tomography were retrospectively assessed. The ratio of the striatum to global (STG) FBB uptake was obtained for each individual, and patients were allotted into low and high STG groups according to the median value. The effect of STG group on regional amyloid deposition, the occurrence of motor complications and longitudinal change in levodopa equivalent dose (LED) requirement were investigated after controlling for age, sex, LED and disease duration at FBB scan. Results: The high STG group was associated with lower cortical FBB uptake in the parietal, occipital and posterior cingulate cortices and higher striatal FBB uptake compared to the low STG group. Patients in the high STG group had a higher risk of developing wearing off and levodopa-induced dyskinesia than those in the low STG group, whereas the risk for freezing of gait was comparable between the two groups. The high STG group showed a more rapid increase in LED requirements over time than the low STG group. Conclusions: These findings suggest that relatively high striatal amyloid deposition is associated with poor motor outcomes in patients with PD.

Original languageEnglish
Article numbere16364
JournalEuropean Journal of Neurology
Volume31
Issue number10
DOIs
Publication statusPublished - 2024 Oct

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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