Association between resting heart rate and arterial stiffness in Korean adults

Byoung Jin Park, Hye Ree Lee, Jae Yong Shim, Jung Hyun Lee, Dong Hyuk Jung, Yong Jae Lee

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Background. - Higher resting heart rate, a simple and useful indicator of autonomic balance and metabolic rate, has emerged as an independent predictor for atherosclerotic cardiovascular disease. Aim. - To determine the association between resting heart rate and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods. - We examined the association between resting heart rate and baPWV in 641 Korean adults (366 men, 275 women) in a health examination program. A high baPWV was defined as greater than 1450 cm/s (> 75th percentile). The odds ratios for high baPWVs were calculated using multivariable logistic regression analysis after adjusting for confounding variables across heart rate quartiles (Q1 ≤ 56, Q2 = 57-62, Q3 = 63-68, Q4 ≥ 69 beats/min). Results. - Age-adjusted baPWV mean values increased gradually with heart rate quartile (Q1 = 1281, Q2 = 1285, Q3 = 1354, Q4 = 1416 cm/s). The odds ratios (95% confidence intervals) for high baPWVs in each heart rate quartile were 1.00, 1.28 (0.57-2.86), 2.63 (1.20-5.79) and 3.66 (1.66-8.05), respectively, after adjusting for age, sex, smoking status, alcohol intake, exercise, body mass index, hypertension medication, diabetes medication, hyperlipidaemia medication, mean arterial blood pressure, fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, white blood cell count, aspartate aminotransferase, alanine aminotransferase, 7-glutamyltransferase and uric acid. Conclusion. - These findings indicate that a higher resting heart rate is independently associated with arterial stiffness. Accordingly, early detection of increased resting heart rate is important for preservation of arterial function and assessment of cardiovascular risk.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalArchives of Cardiovascular Diseases
Issue number4
Publication statusPublished - 2010 Apr

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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