Association between Physical Activity and Telomere Length in Women with Breast Cancer: A Systematic Review

Jihee Min, Ji Young Kim, Ji Yeong Choi, In Deok Kong

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The association between physical activity and telomere length (TL) has been continuously reported. However, the interplay of physical activity and TL among women with breast cancer has not been elucidated. Thus, the purpose of this systematic review was to synthesize the evidence for the association of physical activity with TL in women with breast cancer. Systematic searches were conducted to identify quantified studies using MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, and Clinical Five studies were included in this systematic review. Three of the five studies reported that physical activity has a significant relationship in delaying TL shortening, but others observed no association between physical activity and TL in breast cancer survivors. Although the heterogeneous studies acted as limitations in drawing clear conclusions, physical activity strategies show encouraging impacts in delaying TL shortening. To understand the effects of physical activity on TL shortening in breast cancer survivors, further studies are needed considering the tissue site, treatments for breast cancer, DNA extraction methods, and tools for measuring physical activity.

Original languageEnglish
Article number2527
JournalJournal of Clinical Medicine
Issue number9
Publication statusPublished - 2022 May 1

Bibliographical note

Funding Information:
Funding: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government [No. NRF-2020R1I1A3070520].

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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