Association between fractional flow reserve and coronary plaque characteristics assessed by optical coherence tomography

Seung Yul Lee, Dong Ho Shin, Islam Shehata, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong Ki Hong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background The assessment of fractional flow reserve (FFR) in coronary lesions determines the strategy of percutaneous coronary intervention. However, the association between FFR and characteristics of the underlying coronary plaque has not been sufficiently investigated. Methods A total of 110 coronary lesions in 106 patients were evaluated using both FFR and optical coherence tomography (OCT). Coronary plaques were classified into fibrous, fibrocalcific, or fibroatheroma according to OCT evaluation at the site of minimal lumen area. Plaque microstructures such as cap thickness, macrophage accumulation, intimal vasculature, or cholesterol crystals were also evaluated. Results Lesions with FFR ≤ 0.8 showed a higher frequency of fibroatheroma, macrophage accumulation, and cholesterol crystals when compared to those with FFR > 0.8. The angle of lipid was wider in lesions with FFR ≤ 0.8 (145.1 ± 63.0° vs. 120.7 ± 48.9°, p = 0.047), and the longitudinal length was longer in those with FFR ≤ 0.8 (4.2 ± 2.8 mm vs. 2.5 ± 2.9 mm, p = 0.007). However, multiple linear regression analysis revealed that the morphological characteristics of plaques assessed by OCT were not independently associated with FFR. Minimal lumen area [coefficient, 0.035; 95% confidence interval (CI), 0.022–0.048; p < 0.001] and area stenosis (coefficient, −0.003; 95% CI, −0.005 to −0.001; p = 0.001) assessed by OCT significantly correlated with FFR. Conclusion The morphological characteristics of coronary plaque derived from OCT are not directly related to FFR.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalJournal of Cardiology
Issue number4
Publication statusPublished - 2016 Oct 1

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs , Republic of Korea (Nos. A085136 and A102064 ) and the Cardiovascular Research Center , Seoul, Republic of Korea.

Publisher Copyright:
© 2015 Japanese College of Cardiology

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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