ASSOCIATION between EPIRETINAL MEMBRANE, EPIRETINAL PROLIFERATION, and PROGNOSIS of FULL-THICKNESS MACULAR HOLE CLOSURE

Jee Myung Yang, Sang Uk Choi, Yoon Jeon Kim, Ryul Kim, Dong Keon Yon, Seung Won Lee, Jae Il Shin, Joo Yong Lee, June Gone Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose: To demonstrate the effects of epiretinal membrane (ERM) and epiretinal proliferation on surgical outcomes for full-thickness macular hole. Methods: Nested case–control study with propensity score matching. Patients operated on for full-thickness macular hole between January 2011 and March 2020 were enrolled. The primary outcome was failure of the macular hole closure, and the secondary outcome was unfavorable hole closure (V or l type closure) at 6 months after the surgery. Results: Five hundred and thirty-four eyes of 534 patients met the inclusion criteria. After 1:1 propensity score matching (127 pairs), patients demonstrating ERM were more likely to have a failure of hole closure (adjusted odds ratio, 2.71; 95% confidence interval, 1.19–6.14) and unfavorable hole closure (adjusted odds ratio, 2.07; 95% confidence interval, 1.16–3.71). Epiretinal membrane spanning the hole margin (hole marginal ERM) greatly increased the likelihood of unfavorable hole closure (adjusted odds ratio, 2.13; 95% confidence interval, 1.12–4.07). Patients with hole marginal-ERM + epiretinal proliferation were more likely to have a failure of hole closure (38.4%) compared with those with no ERM (11.8%). Conclusion: Patients with ERM had a higher risk for adverse surgical outcomes for full-thickness macular hole closure. The location of the ERM relative to the macular hole and the presence of epiretinal proliferation might affect the surgical outcomes for full-thickness macular hole closure.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalRetina
Volume42
Issue number1
DOIs
Publication statusPublished - 2022 Jan 1

Bibliographical note

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Fingerprint

Dive into the research topics of 'ASSOCIATION between EPIRETINAL MEMBRANE, EPIRETINAL PROLIFERATION, and PROGNOSIS of FULL-THICKNESS MACULAR HOLE CLOSURE'. Together they form a unique fingerprint.

Cite this