Assembly of iron oxide nanocubes for enhanced cancer hyperthermia and magnetic resonance imaging

Minjung Cho; Antonio Cervadoro; Maricela R. Ramirez; Cinzia Stigliano; Audrius Brazdeikis; Vicki L. Colvin; Pierluigi Civera; Jaehong Key; Paolo Decuzzi

doi:10.3390/nano7040072

Assembly of iron oxide nanocubes for enhanced cancer hyperthermia and magnetic resonance imaging

Minjung Cho, Antonio Cervadoro, Maricela R. Ramirez, Cinzia Stigliano, Audrius Brazdeikis, Vicki L. Colvin, Pierluigi Civera, Jaehong Key, Paolo Decuzzi

Division of Medical Engineering

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r₂ = 678.9 ± 29.0 mM^‒1·s^‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g^‒1 at 512 kHz and 10 kA·m^‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mg_Fe·kg^‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.

Original language	English
Article number	72
Journal	Nanomaterials
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/nano7040072
Publication status	Published - 2017 Apr

Bibliographical note

Funding Information:
This work was partially supported by the Cancer Prevention Research Institute of Texas (CPRIT RP110262); the “pilot projects” of the Translational Imaging Department at the Houston Methodist Hospital; the “George and Angelina Kostas Research Center for Cardiovascular Nanomedicine”; a National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A1A01052592); and the Bio & Medical Technology Development Program (2016M3A9B4919711). This manuscript is dedicated to the memory of our dear friend and colleague Pierluigi Civera, known as “Gigi”.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)
Materials Science(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Assembly of iron oxide nanocubes for enhanced cancer hyperthermia and magnetic resonance imaging",

abstract = "Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 ± 29.0 mM‒1·s‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1 at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.",

author = "Minjung Cho and Antonio Cervadoro and Ramirez, {Maricela R.} and Cinzia Stigliano and Audrius Brazdeikis and Colvin, {Vicki L.} and Pierluigi Civera and Jaehong Key and Paolo Decuzzi",

note = "Funding Information: This work was partially supported by the Cancer Prevention Research Institute of Texas (CPRIT RP110262); the “pilot projects” of the Translational Imaging Department at the Houston Methodist Hospital; the “George and Angelina Kostas Research Center for Cardiovascular Nanomedicine”; a National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A1A01052592); and the Bio & Medical Technology Development Program (2016M3A9B4919711). This manuscript is dedicated to the memory of our dear friend and colleague Pierluigi Civera, known as “Gigi”. Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Cho, Minjung

AU - Cervadoro, Antonio

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AU - Brazdeikis, Audrius

AU - Colvin, Vicki L.

AU - Civera, Pierluigi

AU - Key, Jaehong

AU - Decuzzi, Paolo

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PY - 2017/4

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N2 - Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 ± 29.0 mM‒1·s‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1 at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.

AB - Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 ± 29.0 mM‒1·s‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1 at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.

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Assembly of iron oxide nanocubes for enhanced cancer hyperthermia and magnetic resonance imaging

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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