Are new criteria for mixed histology necessary for endoscopic resection in early gastric cancer?

Hong Jin Yoon, Yong Hoon Kim, Jie Hyun Kim, Hyun Ki Kim, Hoguen Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park, Jong Won Kim, Woo Jin Hyung, Sung Hoon Noh, Seung Ho Choi

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23 Citations (Scopus)


Purpose: Early gastric cancer (EGC) of mixed histology is more aggressive than other histologies. In addition, signet ring cell (SRC) mixed histology shows more submucosal invasion and greater lymph node metastasis (LNM). However, there are no criteria for endoscopic resection (ER) in mixed histology. Therefore, this study investigated whether new criteria for mixed histology are necessary for ER in EGC. Methods: From January 2005 to December 2012, 3419 patients with EGC underwent surgery. Lesions were classified using three histological classifications: the Japanese classification; World Health Organization (WHO) classification including SRC mixed histology; and Lauren classification. The mixed type in the Lauren classification was also reclassified according to the proportion of differentiated and undifferentiated components. Clinicopathological characteristics were compared according to histological classifications, with special reference to the ER criteria. Results: With the Lauren classification, 179 (5.3%) lesions were classified as mixed type, including 54 (30.2%) lesions as the differentiated-predominant mixed type. There were 361 (10.6%) lesions classified as SRC mixed histology. Mixed-type lesions in the Lauren classification and SRC mixed lesions were significantly associated with larger size and a greater LNM. Among the lesions meeting the ER criteria, 20 (1.6%) and 55 (4.7%) were categorized as mixed type by the Lauren classification and SRC mixed histology, respectively. However, there was no LNM among the lesions recategorized into mixed histology. Conclusions: Mixed histology showed no LNM among the lesions met the present ER criteria. Thus, separate criteria for mixed histology might be not necessary in the criteria for ER in EGC.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalPathology Research and Practice
Issue number5
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2012R1A1A1042417 ). The authors thank Mr. Dong-Su Jang, Research Assistant, Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea, for his help with the figure.

Publisher Copyright:
© 2016 Elsevier GmbH.

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology


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