Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion

Ki Hyoung Koo, Jung Min Ahn, Jong Min Lee, Byung Soo Kim, Chang Sung Kim, Gun Il Im

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Bone morphogenetic proteins (BMPs) need an effective delivery system for efficient bone regeneration. In this study, we evaluated the efficiency of an apatite-coated collagen sponge for the long-term delivery of BMP-2 in a rabbit model of lumbar posterolateral fusion. A total of 15 rabbits, divided into three groups, underwent posterolateral lumbar fusion. The first group (control group) received uncoated collagen sponges without BMP-2. The second group (uncoated group) received uncoated collagen sponges with BMP-2 (40μg each side). The third group (apatite-coated group) received apatite-coated collagen sponges with the same level of BMPs (40μg each side). All rabbits were euthanized 6 weeks after operation, and the fusion status was assessed by radiographic study, micro-CT, manual palpation, biomechanical study, and histological examination. Fusion rates as determined by radiographic study, micro-CT, and manual palpation showed that the apatite-coated group had a significantly higher rate of fusion than the control group (P=0.024), while the uncoated group did not (P=0.083). Biomechanical study showed significantly higher tensile strength in the apatite-coated group than the uncoated group (P=0.032). Denser trabeculations were found in the apatite-coated group compared with the uncoated group. It is concluded that the use of apatite-coated collagen sponges for BMP-2 delivery enhanced bone regeneration.

Original languageEnglish
Pages (from-to)893-899
Number of pages7
JournalArtificial Organs
Issue number10
Publication statusPublished - 2014 Oct 1

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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